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M9490324.TXT
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1994-09-19
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Document 0324
DOCN M9490324
TI [The use of a primary astrocyte culture for modelling HIV neurological
infection]
DT 9411
AU Rytik PG; Kvacheva ZB; Eremin VF; Poleshchuk NN; Popov SA; Muller WB;
Asher DM
SO Zh Mikrobiol Epidemiol Immunobiol. 1993 Mar-Apr;(2):47-52. Unique
Identifier : AIDSLINE MED/94337564
AB The article deals with the results of the experiment substantiating the
in vitro model of HIV neuro-infection. In this work primary glial
(astrocytic) tissue cultures obtained from normal human and animal
(guinea pig) brain tissue were used. As revealed in this investigation,
the following phenomena could be observed in human brain tissue
monolayer culture, infected with HIV and subsequently subcultured: (a)
the stimulation of tissue-cell growth; (b) the formation of multinuclear
glial cells; (c) the presence of virus-specific proteins in astrocyte
cytoplasm, detected by immunofluorescent and electrophoretic techniques;
(d) the presence of HIV-1 DNA provirus in infected astrocytes.
Cyto-destruction was not observed, reverse transcriptase activity was
absent.
DE Animal Animals, Newborn Astrocytes/*MICROBIOLOGY/ULTRASTRUCTURE AIDS
Dementia Complex/*MICROBIOLOGY/PATHOLOGY Cell Line Cells, Cultured
*Disease Models, Animal English Abstract Guinea Pigs Human *HIV-1
Microscopy, Electron Microscopy, Phase-Contrast JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).